A study of iris melanoma in Northern Ireland.
نویسندگان
چکیده
A retrospective study of all cases of iris melanoma in Northern Ireland over a 15-year period was undertaken. A total of 18 cases were identified. Of these, nine were histologically proved to be iris melanomas of various types. Within the period of follow-up two patients died from metastatic deposits. In both cases invasion of the anterior face of the ciliary body was present on histological examination. The implications for management are discussed.
منابع مشابه
Increasing mortality from malignant melanoma among women in Northern Ireland
Deaths from malignant melanoma in each part of the British Isles between 1969 and 1984 have been examined. There has been a substantial increase of deaths among women in each part, and an increase of similar magnitude among men in all areas except Northern Ireland. It is suggested that this difference requires further study. The increasing number of deaths from this disease indicates a need for...
متن کاملEpidemiology and management of uveal melanoma.
Uveal melanoma is the most common primary intraocular malignancy in adults. The disease overwhelmingly affects white populations. Other risk factors include fair skin, light iris color, ancestry from northern latitudes, and ocular/oculodermal melanocytosis. Historically, enucleation was the definitive treatment of uveal melanoma, but brachytherapy and proton beam irradiation are now the most co...
متن کاملAssociation between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi.
AIM To investigate the association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi. METHODS Cross sectional study of 65 patients with posterior uveal melanoma and 218 controls. Iris colour, iris freckles, iris naevi, and choroidal naevi were recorded for each eye of each patient. RESULTS Iris freckles were present in 40 (61.5%) patients with melanoma and ...
متن کاملThe T1799A BRAF mutation is present in iris melanoma.
PURPOSE An activating mutation in exon 15 of the BRAF gene has been found in a high proportion of cutaneous pigmented lesions, but only in one case of uveal melanoma. Iris melanoma is the least common uveal melanoma and displays a less aggressive clinical course compared with posterior uveal melanoma. To date, no study has been conducted to investigate the T1799A mutation in iris melanoma. The ...
متن کاملCollaboration on the West Coast
Three hundred and four suspected cases of malignant melanoma diagnosed in Northern Ireland over a 5 year period have been reviewed. Two hundred and forty fulfilled the diagnostic criteria of invasive cutaneous malignant melanoma (CMM) and were accepted as suitable for analysis an incidence of 3.12. The female to male ratio for CMM in this study is 3:1. This excess of female lesions occurs at al...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The British journal of ophthalmology
دوره 73 8 شماره
صفحات -
تاریخ انتشار 1989